Medical news network August 4th day ago, a study published in the International Journal of the Journal of the National Cancer report on Institute, researchers from the University of Southampton found through research, targeting of cancer cells by intercept healthy cells or to help the treatment of many types of human diseases, related research funded by cancer research center british.
In this article, the researchers found that targeted the effects of enzymes called NOX4 may block called cancer associated fibroblasts (CAFs) activity, which can be reduced in mice tumor size up to 50%. Fibroblast is a kind of healthy cells in the body, which can play an important role in a variety of organs, but when these cells are cancer cells blocked, it will become CAFs, will also help tumor growth, diffusion and resist cancer therapy attack, so far, the researchers try to effect the cell targeting has not been successful.
Prior to the study, the researchers found that high levels of CAFs in the body were directly related to the poor survival rates in many types of cancer, including colorectal cancer and head and neck cancer. In this study, researchers first discovered that NOX4 enzymes for the formation of CAFs and help to promote the necessary types of tumor growth, but the use of drugs for the treatment of organ fibrosis occurs blocking the function of NOX4 may be able to inhibit the process.
Provides a new way for researchers to research or development of new therapies for diseases, but also can promote cancer have a better response to the drug, the Cancer Research UK funded scientists of the University of Southampton is to observe whether the new method can improve the immune therapy and chemotherapy which therapy is more effective. "By looking at several types of cancer, we identified a specific mechanism that effectively responds to the formation of CAFs in tumors," said researcher Gareth Thomas.
These cells can make cancer more invasive and difficult to treat, but researchers may now target cancer patients who do not respond to current therapies by targeting these cells. Some cancers are often difficult to treat, and cancer cells will often help cancer growth by host cells, avoid therapy attacks, even spread in the body; researchers now want to study to the mystery hidden for years, but the study for researchers eventually find the true answer or moving forward a step.
Finally, the researchers said, the use of special drugs or to achieve the CAFs target, and now researchers have realized the effect to reverse the tumor promoting in mice in vivo. The related research has provided a new hope and research foundation for the future development of new and more effective therapy researchers.
